Pioglitazone decrease intrapulmonary shunt in biliary cirrhotic rats with hepatopulmonary syndrome
نویسندگان
چکیده
منابع مشابه
Sorafenib treatment improves hepatopulmonary syndrome in rats with biliary cirrhosis.
HPS (hepatopulmonary syndrome) is characterized by oxygen desaturation in patients with chronic liver disease. The initiation of HPS comes from abnormal pulmonary vasodilatation and/or angiogenesis. In the present study, we evaluated anti-angiogenesis therapy using sorafenib in experimental HPS animals. HPS was induced by CBDL (common bile duct ligation) in rats. A 2-week 10 mg·(kg of body weig...
متن کاملIntrapulmonary shunt confirmed by intracardiac echocardiography in the diagnosis of hepatopulmonary syndrome.
H epatopulmonary syndrome (HPS) occurs in the setting of liver disease when oxygenation is impaired as a result of intrapulmonary vascular dilatation. The exact mechanism is not entirely clear, but is felt to be related to increases in pulmonary vasodilators, such as nitric oxide. Diagnosis requires the presence of liver disease, inadequate oxygenation, and confirmation of intrapulmonary shunti...
متن کاملFrequency of hepatopulmonary syndrome in cirrhotic patients.
OBJECTIVE To determine the frequency of Hepatopulmonary Syndrome (HPS) in patients with cirrhosis of the liver. STUDY DESIGN Observational cross-sectional study. PLACE AND DURATION OF STUDY Department of Gastroenterology and Hepatology, Shaikh Zayed Hospital, Lahore, from April 2005 to March 2006. PATIENTS AND METHODS Fifty consecutive patients admitted with liver cirrhosis were recruited...
متن کاملDual organ beneficial effects of metformin in cirrhotic rats with hepatopulmonary syndrome.
Liver fibrosis causes portal hypertension which dilates collateral vasculature and enhances extra-hepatic angiogenesis including intrapulmonary shunts, which subsequently complicates with hepatopulmonary syndrome (HPS). Metformin is an anti-diabetic agent which has anti-inflammation and antiangiogenesis properties. HPS is a severe complication of liver cirrhosis which is characterized by deoxyg...
متن کاملExercise capacity of cirrhotic patients with hepatopulmonary syndrome.
INTRODUCTION Hepatopulmonary syndrome (HPS) is characterized by a clinical triad of liver disease and/or portal hypertension, intrapulmonary vascular dilatation and abnormal arterial oxygenation. These conditions can worsen muscle strength, exercise capacity and functionality in the affected population. OBJECTIVE The objective of this study was to compare exercise capacity, functional conditi...
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ژورنال
عنوان ژورنال: Journal of the Chinese Medical Association
سال: 2017
ISSN: 1726-4901
DOI: 10.1016/j.jcma.2017.08.005